잠시만 기다려 주세요. 로딩중입니다.

Long-term Prognosis of Mild to Moderate Aortic Stenosis and Coronary Artery Disease

Journal of Korean Medical Science 2021년 36권 6호 p.47 ~ 47
이원재, 최원석, 강시혁, 황인창, 최홍미, Yoon Yeon-Yee E., 조구영,
소속 상세정보
이원재 ( Lee Won-Jae ) - Seoul National University College of Medicine Department of Internal Medicine
최원석 ( Choi Won-Suk ) - Seoul National University College of Medicine Department of Internal Medicine
강시혁 ( Kang Si-Hyuck ) - Seoul National University College of Medicine Department of Internal Medicine
황인창 ( Hwang In-Chang ) - Seoul National University College of Medicine Department of Internal Medicine
최홍미 ( Choi Hong-Mi ) - Hallym University College of Medicine Hallym University Sacred Heart Hospital Division of Cardiology
 ( Yoon Yeon-Yee E. ) - Seoul National University College of Medicine Department of Internal Medicine
조구영 ( Cho Goo-Yeong ) - Seoul National University College of Medicine Department of Internal Medicine

Abstract


Background: There is an incomplete understanding of the natural course of mild to moderate aortic stenosis (AS). We aimed to evaluate the natural course of patients with mild to moderate AS and its association with coronary artery disease (CAD).

Methods: We retrospectively analyzed 787 patients diagnosed with mild to moderate AS using echocardiography between 2004 and 2010. Cardiac death and aortic valve replacement (AVR) for AS were assessed.

Results: A median follow-up period was 92 months. Compared to the general population, patients with mild to moderate AS had a higher risk of cardiac death (hazard ratio [HR], 17.16; 95% confidence interval [CI], 13.65?21.59; P < 0.001). Established CAD was detected in 22.4% and associated with a significantly higher risk of cardiac mortality (adjusted HR, 1.62; 95% CI, 1.04?2.53; P = 0.033). The risk of cardiac death was lower when patients were taking statin (adjusted HR, 0.64; 95% CI, 0.41?0.98; P = 0.041), which was clear only after 7 years. Both patients with CAD and on statin tended to undergo more AVR, but the difference was not statistically significant (the presence of established CAD; adjusted HR, 1.63; 95% CI, 0.51?3.51; P = 0.214 and the use of statin; adjusted HR, 1.86; 95% CI, 0.76?4.58; P = 0.177).

Conclusion: Mild to moderate AS does not have a benign course. The presence of CAD and statin use may affect the long-term prognosis of patients with mild to moderate AS.

키워드

Aortic Stenosis; Prognosis; Coronary Artery Disease

원문 및 링크아웃 정보

 

등재저널 정보