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Prognostic Implications of CT Feature Analysis in Patients with COVID-19: a Nationwide Cohort Study

Journal of Korean Medical Science 2021년 36권 8호 p.51 ~ 51
정연주, 남보다, 유진영, 김건일, 강희, 황정화, 김윤현, 이경수,
소속 상세정보
정연주 ( Jeong Yeon-Joo ) - Pusan National University Hospital Department of Radiology
남보다 ( Nam Bo-Da ) - Soonchunhyang University College of Medicine Soonchunhyang University Seoul Hospital Department of Radiology
유진영 ( Yoo Jin-Young ) - Chungbuk National University Hospital Department of Radiology
김건일 ( Kim Kun-Il ) - Pusan National University Yangsan Hospital Department of Radiology
강희 ( Kang Hee ) - Kosin University Gospel Hospital Department of Radiology
황정화 ( Hwang Jung-Hwa ) - Soonchunhyang University College of Medicine Soonchunhyang University Seoul Hospital Department of Radiology
김윤현 ( Kim Yun-Hyeon ) - Chonnam National University Hospital Department of Radiology
이경수 ( Lee Kyung-Soo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiology

Abstract


Background: Few studies have classified chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) and analyzed their correlations with prognosis. The present study aimed to evaluate retrospectively the clinical and chest CT findings of COVID-19 and to analyze CT findings and determine their relationships with clinical severity.

Methods: Chest CT and clinical features of 271 COVID-19 patients were assessed. The presence of CT findings and distribution of parenchymal abnormalities were evaluated, and CT patterns were classified as bronchopneumonia, organizing pneumonia (OP), or diffuse alveolar damage (DAD). Total extents were assessed using a visual scoring system and artificial intelligence software. Patients were allocated to two groups based on clinical outcomes, that is, to a severe group (requiring O2 therapy or mechanical ventilation, n = 55) or a mild group (not requiring O2 therapy or mechanical ventilation, n = 216). Clinical and CT features of these two groups were compared and univariate and multivariate logistic regression analyses were performed to identify independent prognostic factors.

Results: Age, lymphocyte count, levels of C-reactive protein, and procalcitonin were significantly different in the two groups. Forty-five of the 271 patients had normal chest CT findings. The most common CT findings among the remaining 226 patients were ground-glass opacity (98%), followed by consolidation (53%). CT findings were classified as OP (93%), DAD (4%), or bronchopneumonia (3%) and all nine patients with DAD pattern were included in the severe group. Uivariate and multivariate analyses showed an elevated procalcitonin (odds ratio [OR], 2.521; 95% confidence interval [CI], 1.001?6.303, P = 0.048), and higher visual CT scores (OR, 1.137; 95% CI, 1.042?1.236; P = 0.003) or higher total extent by AI measurement (OR, 1.048; 95% CI, 1.020?1.076; P < 0.001) were significantly associated with a severe clinical course.

Conclusion: CT findings of COVID-19 pneumonia can be classified into OP, DAD, or bronchopneumonia patterns and all patients with DAD pattern were included in severe group. Elevated inflammatory markers and higher CT scores were found to be significant predictors of poor prognosis in patients with COVID-19 pneumonia.

키워드

Chest; Coronavirus; COVID-19; Tomography, X-Ray Computed; Pneumonia; Prognosis

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