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The Mediating Effect of Insomnia on the Relationship between Panic Symptoms and Depression in Patients with Panic Disorder

Journal of Korean Medical Science 2021년 36권 9호 p.30 ~ 30
홍수민, 김설민, 박두흠, 유승호, 하지현, 전홍준,
소속 상세정보
홍수민 ( Hong Su-Min ) - Konkuk University Medical Center Department of Psychiatry
김설민 ( Kim Seol-Min ) - Konkuk University Medical Center Department of Psychiatry
박두흠 ( Park Doo-Heum ) - Konkuk University Medical Center Department of Psychiatry
유승호 ( Ryu Seung-Ho ) - Konkuk University Medical Center Department of Psychiatry
하지현 ( Ha Jee-Hyun ) - Konkuk University Medical Center Department of Psychiatry
전홍준 ( Jeon Hong-Jun ) - Konkuk University Medical Center Department of Psychiatry

Abstract


Background: This study aimed to determine if sleep disturbances may mediate the relationship between panic symptoms and depression in patients with panic disorder (PD).

Methods: Electronic medical records were retrospectively reviewed for 110 consecutive patients with diagnosed PD in an outpatient clinic between October 2018 and December 2019. Measurements include the PD Severity Scale, Beck Depression Inventory-II (BDI-II) and Insomnia Severity Index (ISI). Statistical analyses were performed to assess any potential relationship between PD, insomnia and depression.

Results: Of the PD patients, 88 (80%) and 89 (80.9%) had comorbid depression (BDI-II ≥ 14) and insomnia (Korean version of the ISI ≥ 8), respectively. In a mediation model using insomnia as the mediating variable, the total effect of panic symptom severity on depression was significant (t = 7.23, P < 0.001). There were significant effects of panic symptoms on insomnia (t = 4.62, P < 0.001) and of insomnia on depression (t = 6.69, P < 0.001). The main effect of panic symptom severity on depression was also significant, after controlling for the effect of insomnia (t = 5.10, P < 0.001), suggesting partial mediation.

Conclusion: Both depressive symptoms and insomnia are common in patients with PD and depression was partially mediated by insomnia in these patients. These results suggest that an intervention for insomnia in patients with PD might help prevent the development of depression.

키워드

Panic Disorder; Insomnia; Depression; Mediator; Comorbidity

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