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Performance Changes Following the Revision of Organ Allocation System of Lung Transplant: Analysis of Korean Network for Organ Sharing Data

Journal of Korean Medical Science 2021년 36권 12호 p.79 ~ 79
여혜주, 김도형, 김윤성, 전두수, 조우현,
소속 상세정보
여혜주 ( Yeo Hye-Ju ) - Pusan National University Yangsan Hospital Department of Internal Medicine
김도형 ( Kim Do-Hyung ) - Pusan National University Yangsan Hospital Department of Thoracic and Cardiovascular Surgery
김윤성 ( Kim Yun-Seong ) - Pusan National University Yangsan Hospital Department of Internal Medicine
전두수 ( Jeon Doo-Soo ) - Pusan National University Yangsan Hospital Department of Internal Medicine
조우현 ( Cho Woo-Hyun ) - Pusan National University Yangsan Hospital Department of Internal Medicine

Abstract


Background: There is currently a lack of data on the impact of the recent revision of the domestic lung allocation system on transplant performance.

Methods: We conducted a retrospective analysis of transplant candidates and transplant patients registered in Korean Network for Organ Sharing between July 2015 and July 2019. Study periods were classified according to the introduction of the revised lung allocation system as follows: period 1 from July 2015 to June 2017 and period 2 from August 2017 to July 2019.

Results: During the study period, a total of 627 patients were on the waiting list, of which 398 lung transplantations were performed. Total waiting list size increased by 98.6%, from 210 in period 1 to 417 in period 2. The number of transplant patients also increased by 32.7%, from 171 in period 1 to 227 in period 2. The number of donors decreased from 1,042 to 878, whereas the usage rate, i.e., the number of lung donors used for transplantation among the total number of reported lung donors, increased from 16.4% to 25.9%. The proportion of patients with high urgent status at transplantation increased from 45% to 60.4%, whereas those with urgent status decreased from 46.8% to 35.7% (P = 0.006). The use of marginal donor lungs increased from 29.8% to 53.7% (P < 0.001). To adjust urgency status and marginal donor usage between two groups, we conducted a propensity score matching analysis. No significant differences were detected in 1-year survival rates between the two periods after propensity score matching. As well, no significant difference was observed in mortality on the waiting list between the two periods.

Conclusion: The recent revision of the lung allocation system in Korea did not change the performance of lung transplant in terms of waiting list mortality and 1-year survival. The rapid increase in the volume of waiting list between the two periods increased the waiting time, transplantation of high-urgency patients, and use of marginal lung donors.

키워드

Lung Transplantation; Lung Allocation System; Korea; Mortality

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