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Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study

Korean Journal of Ophthalmology 2017년 31권 4호 p.306 ~ 312
이관복, 고경민, 권영아, 송상률, 김병엽, 정재림,
소속 상세정보
이관복 ( Lee Kwan-Bok ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology
고경민 ( Koh Kyung-Min ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology
권영아 ( Kwon Young-A ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology
송상률 ( Song Sang-Wroul ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology
김병엽 ( Kim Byoung-Yeop ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology
정재림 ( Chung Jae-Lim ) - Konyang University College of Medicine Kim’s Eye Hospital Department of Ophthalmology

Abstract


Purpose: To evaluate changes in the tear meniscus area and tear meniscus height over time in patients with dry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillation of 3% diquafosol ophthalmic solution.

Methods: Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscus images acquired by anterior segment spectral-domain optical coherence tomography were analyzed using National Institutes of Health's image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscus height were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosol in one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear film break-up time, corneal staining score by Oxford schema, and meibomian expressibility were also evaluated at baseline, and after 1 week and 1 month of a diquafosol daily regimen.

Results: Sixty eyes from 30 subjects (mean age, 29.3 years; 8 men and 22 women) were included. In eyes receiving diquafosol, tear volume was increased at 5 and 10 minutes compared with baseline. It was also higher than saline instilled eyes at 5, 10, and 30 minutes. Changes in tear volume with respect to baseline were not statistically different after the use of diquafosol for 1 month. Ocular surface disease index score, tear film break-up time, and Oxford cornea stain score were significantly improved after 1 week and 1 month of daily diquafosol instillation, but meibomian expressibility did not change.

Conclusions: Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes, compared to normal saline in patients with dry eye syndrome.

키워드

Diquafosol; Ophthalmic solutions; Purinergic P2Y receptor agonists; Tear meniscus; Tears secretion

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