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Urea Synthesis in the Intact and in the Isolated Perfused Liver of the Biotin-Deficient Rats

Yonsei Medical Journal 1971년 12권 1호 p.13 ~ 16
김제현, 조무연, 김병우, Song Chug-Suk,
소속 상세정보
김제현 ( Kim Je-Hyun ) - 연세대학교 의과대학 생화학교실
조무연 ( Cho Moo-Youn ) - 연세대학교 의과대학 생화학교실
김병우 ( Kim Byung-Woo ) - 연세대학교 의과대학 생화학교실
 ( Song Chug-Suk ) - 연세대학교 의과대학 생화학교실

Abstract


Biotin-deficient rats were raised on a purified ration containing raw egg white plus avidin. Urea synthesis and excretion were compared between the biotin-deficient and the pair-fed control rats. 24hrurinary urea excretion and the specific activities of carbamylphosphate synthetase, ornithine transcarbamylase, and arginase in the liver mitochondria fraction were no different between these two groups.

The net urea production in the liver slice and in the isolated perfused liver of the biotin-deficient rats was similar to that of the pair-fed control. Thus the conclusion must be that biotin is not in urea in mea biosynthesis in the rat.

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