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Effect of Thyroxine on the Cardiac Uptake of Catecholamines

Yonsei Medical Journal 1971년 12권 1호 p.17 ~ 20
Yoo Chong-Sup, Chu Young-Myong, Lee Woo-Choo,
소속 상세정보
 ( Yoo Chong-Sup ) - 연세대학교 의과대학 약리학교실
 ( Chu Young-Myong ) - 연세대학교 의과대학 약리학교실
 ( Lee Woo-Choo ) - 연세대학교 의과대학 약리학교실

Abstract


The influence of thyroxine upon n the cardiac uptake of catecholamines was investigated in rabbits. A single injection of thyroxine(1.0m/kg) into rabbits did not affect the concentration of myocardial catecholamines. However, this dose of thyroxine greatly increased the cardiac uptake of catecholamine following injection of 2.0mg of norepinephrine as compared to that of untreated normal animals and it remained elevated for several hours. Similarly thyroxine also enhanced the accumulation of myocardial catecholamines following administration of dopa(60-80mg/kg) and epinephrine(1.0-1.5mg/kg).

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