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Pyroninophilic Granules in Liver Cells of the Mice Treated with Alpha-Tocopherol and Thioacetamide

Yonsei Medical Journal 1972년 13권 1호 p.40 ~ 49
신태선, Kang Ho-Suck, Choi Kum-Duck, 이규식, Shin Duk-Chong,
소속 상세정보
신태선 ( Shin Tai-Sun ) - 연세대학교 의과대학 해부학교실
 ( Kang Ho-Suck ) - 연세대학교 의과대학 해부학교실
 ( Choi Kum-Duck ) - 연세대학교 의과대학 해부학교실
이규식 ( Lee Kyu-Sik ) - 연세대학교 의과대학 해부학교실
 ( Shin Duk-Chong ) - 연세대학교 의과대학 해부학교실

Abstract


In an attempt to clarify the protective action of an antioxidant agent against acute toxicity of thioacetamide (TAA) and in order to throw some light on an satisfying concept of the mechanism of its action, a single dose of alphatocopherol (200 mg per kg) was given orally by stomch tube to male mice prior to the administration of thioacetamide in a dose of 200 mg per kg of body weight. Sections of liver samples, obtained from the mice which were sacrificed at intervals of 3, 6, 9, or 12 hours after TAA administration, were stained using the methyl green-pyronin technique.

At 3 hours following TAA administration, the pretreatment with alpha-tocopherol inhibited almost completely such alterations of the hepatocytes in the animals given TAA alone, as revealed by loss and clumping of cytoplasmic pyroninophilic granules in the periportal zone of the lobule.

At 6, 9, and l2 hours, the prevention of alpha-tocopherol was incomplete in degree and extent. The changes of the hepatocytes were more intense and extensive in the TAA-treated 6 to 12 hour-groups than in the 3 hour-group of TAA-treated ones.

Some discussion is given of the mechanism of TAA toxicity, with respect to the microsoma1 lipid peroxidation.

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