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Effects of Some Local Anesthetics on Ca++ Binding to Lipid-Extracted RBC Membrane, Egg Albumin Film and Filter Paper

Yonsei Medical Journal 1973년 14권 1호 p.1 ~ 9
Kim Johng-Suk, 하종식, 강두희,
소속 상세정보
 ( Kim Johng-Suk ) - 연세대학교 의과대학 생리학교실
하종식 ( Hah Jong-Sik ) - 연세대학교 의과대학 생리학교실
강두희 ( Kang Doo-Hee ) - 연세대학교 의과대학 생리학교실

Abstract


Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1).

A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.

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