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Hematological Aspects of Congenital Syphilis

Yonsei Medical Journal 1976년 17권 2호 p.142 ~ 150
Kim Kir-Young, 김수형,
소속 상세정보
 ( Kim Kir-Young ) - Yonsei University College of Medicine Department of Pediatrics
김수형 ( Kim Soo-Hyung ) - Yonsei University College of Medicine Department of Pediatrics

Abstract


Hematologic investigations for 7 years at the Pediatric Department of Yonsei Medical Center of 52 syphilitic infants were reviewed. A moderate degree of anemia with red cell regeneration was observed in 40 infants (76.0 %). Marked thrombocytopenia but without active bleeding was found in 19 infants, and with active bleeding in 3 infants. A wide range of leukocyte counts, relative lymphocytosis and monocytosis were prominant features. The jaundice was mainly due to unconjugated bilirubin in 6 infants, conjugated as well as unconjugated bilirubin in 8 infants. With therapy, the above abnormal hematologic findings showed marked improvement. Early diagnosis is essential. Prevention and congenital syphilis depend on a high level of clinical suspicion, supported by routine and diagnostic use of laboratory and serologic aids, in the asymptomatic or minimally symptomtaic infants.

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