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Cytogenetic Studies of Peripheral Leukocytes following Surgery and Radiotherapy in Patients with Breast Carcinoma

Yonsei Medical Journal 1977년 18권 2호 p.136 ~ 139
Hahn Sahsook,
소속 상세정보
 ( Hahn Sahsook ) - Yonsei University College of Medicine Department of Pathology

Abstract


Chromosome analysis were carried out on peripheral blood leukocytes of breast cancer patient during the irradiation therapy after unilateral simple mastectomy. The observations were made at intervals varying from one to 5 weeks during the therapy and one month after the completion of the treatment. During the first and second weeks of treatment normal metaphase was noted and during the 4th and 5 th weeks, there were no mitotic figures from the cell population. The chromosomal aberrations found after 3 weeks of treatment were, 11% of simple chromatid breaks, 7% of chromatid interchanges (translocations) and 8% of fragments. One month after the completion of the course of treatment showed a return of mitosis and that total chromatid breaks had decreased to 5%.
Radiation effects on cell division and chromosome aberration are discussed.

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