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Detailed Analysis of Chromosome Aberrations in Human Leukocyte Induced by Anti-malignant Tumor Agent (FT-207)

Yonsei Medical Journal 1978년 19권 1호 p.7 ~ 15
Hahn Sahsook, 김동식,
소속 상세정보
 ( Hahn Sahsook ) - Yonsei University College of Medicine Department of Pathology
김동식 ( Kim Dong-Sik ) - Yonsei University College of Medicine Department of Pathology

Abstract


The anticancer agent´s, FT-207, N₁-(2´-tetrahydrofuryl)-5-fluorouracil, a derivative of 5FU (5-fluorouracil), induced chromosome damage to the human leukocyte was investigated. FT-207 inhibit mitosis and cause chromatid and chromosome breakage and chromatid exchange with 20 ㎍/㎖ for 48 to 72 hours of treatment. However, with 15 ㎍/㎖ for 72 hours only delayed spiralization was produced in some of the chromosomes in the same cells.
The random distribution of chromosome breakage were observed and the effect of FT-207 on the chromosomes of human leukocytes were time dependent rather than concentration dependent. The comparision of the effect of mitomycin C on human leukocytes and the action of FT-207 at specific times during the cell cycle were discussed.

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