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Mechanism of Neuronal Migration in Human Foetal Cerebrum In-vitro

Yonsei Medical Journal 1979년 20권 2호 p.92 ~ 104
최병호,
소속 상세정보
최병호 ( Choi Byung-Ho ) - University of Rochester School of Medicine and Dentistry Department of Pathology Division of Neuropathology

Abstract


Active migration of immature neurons occurs when fragments of human foetal cerebral tissues are explanted as organotypic cultures. The sequence of events during neuronal migration is orderly and consistent under different cultural conditions as evidenced by continuous time-lapse cinematographic studies. Migrating neurons utilize astrocytes to anchor neurites, and move in clusters on or along the processes of astrocytes or other neurons. Translocation of neuronal soma is accomplished by nuclear movement within extended neurites. A unique junction develops between neurites and astrocytic membrane during early phases in culture to suggest a special affinity of neu-ons to astrocytes. It is concluded from these observations that immature neurons have inherent capacity for active migration in-vitro; preferentially utilize astrocytes and astrocytic processes for anchoring as well as for directional guidance during migration; and translocate their soma by nuclear movement within extended neurites.
It is suggested that similar mechanisms may be at play during migration of postmitotic neurons in developing cerebral cortex in human.

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