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The Production of Micronuclei from Chromosome Aberrations by Chemical Carcinogens in Mice

Yonsei Medical Journal 1979년 20권 2호 p.105 ~ 112
Hahn Sahsook, 김동식,
소속 상세정보
 ( Hahn Sahsook ) - Yonsei University College of Medicine Department of Pathology
김동식 ( Kim Dong-Sik ) - Yonsei University College of Medicine Department of Pathology

Abstract


The effect of four alkylating agents(MMS, EMS, DMN, DEM), under various concentrations on mouse bone marrow erythrocytes, were studied by means of the micronucleus test. The results obtained were as follows:
1) The lethal doses on mice were MMS=130 ㎎/㎏/bw, EMS= 300 ㎎/㎏/bw, DMN=50 ㎎/㎏/bw and DEN= 70 ㎎/㎏/bw.
2) Micronuclei were easily seen and in different controls the micronulei were found a little over 0.1 %.
3) The dose-effect relationship was obtained. In the MMS and EMS treated groups, incidences of micronulei were 0.45 to 2.56% and 0.4 to 2.1%respectively.
4) In the DMN and DEN treated groups, inidences varied between 0.15 to 0.90% and 0.2 to 1.02% respectively.
5) Four alkylating agents were compared and discussed with respect to micro nucleus production from chromosomal aberrations.

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