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Analysis of Adverse Drug Reactions with Carbamazepine and Oxcarbazepine at a Tertiary Care Hospital

Yonsei Medical Journal 2020년 61권 10호 p.875 ~ 879
이정은, 민강렬, 김수현, 김형택, 김성택,
소속 상세정보
이정은 ( Lee Jung-Eun ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
민강렬 ( Min Kang-Ryul ) - Lake Forest College Department of Biology
김수현 ( Kim Soo-Hyun ) - Yonsei University Healthcare System Department of Pharmacy
김형택 ( Kim Hyung-Tack ) - University of California TMJ & Orofacial Pain Clinic
김성택 ( Kim Seong-Taek ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine

Abstract


Purpose: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period.

Materials and Methods: The frequency and clinical features of ADRs caused by CBZ and OXC were analyzed using the pharmacovigilance database and spontaneous ADR reporting data of Yonsei University Severance Hospital & Dental Hospital (Seoul, Korea) from January 1, 2010 to January 31, 2020.

Results: Among 10419 cases prescribed CBZ and OXC, 204 ADR cases were reported. The incidences of ADRs were 1.8% and 2.2% for CBZ and OXC respectively, with no significant difference (p=0.169). The most common clinical presentations were skin disorders. Female patients had relatively more frequent ADRs than male patients. Although mild skin ADRs were more frequent with OXC, nervous system disorders, general disorders, and hepatobiliary disorders occurred more often with CBZ. There were six reports of severe cutaneous adverse reactions to CBZ, while OXC had none. Both CBZ and OXC caused ADRs at daily doses lower than the recommended initial dose.

Conclusion: Due to lower incidence of severe ADRs with OXC than CBZ, we suggest OXC as a first-line prescription.

키워드

Carbamazepine; oxcarbazepine; drug related adverse reactions; anticonvulsants

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