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Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis

Yonsei Medical Journal 2020년 61권 10호 p.891 ~ 894
박지혜, 정다은, 정연욱, 김다혜, 천재희, 류지환,
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박지혜 ( Park Ji-Hye ) - Yonsei University College of Medicine Department of Internal Medicine
정다은 ( Jeong Da-Eun ) - Yonsei University College of Medicine Severance Biomedical Science Institute
정연욱 ( Chung Youn-Wook ) - Yonsei University College of Medicine Severance Biomedical Science Institute
김다혜 ( Kim Da-Hye ) - Yonsei University College of Medicine Severance Biomedical Science Institute
천재희 ( Cheon Jae-Hee ) - Yonsei University College of Medicine Department of Internal Medicine
류지환 ( Ryu Ji-Hwan ) - Yonsei University College of Medicine Severance Biomedical Science Institute

Abstract


The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Beh?et's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.

키워드

Coronavirus; SARS-CoV-2; COVID-19; angiotensin converting enzyme 2; proteomics

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