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Association between BDNF Polymorphism and Depressive Symptoms in Patients Newly Diagnosed with Type 2 Diabetes Mellitus

Yonsei Medical Journal 2021년 62권 4호 p.359 ~ 365
Ryu Jin-Sun, 이영미, 김유식, 강신애, 박종숙, 안철우, 남지선, 석정호,
소속 상세정보
 ( Ryu Jin-Sun ) - Yonsei University College of Medicine Department of Psychiatry
이영미 ( Lee Young-Mi ) - Dongtan Jeil Women’s Hospital Department of Internal Medicine
김유식 ( Kim Yu-Sik ) - Yonsei University College of Medicine Severance Institute for Vascular and Metabolic Research
강신애 ( Kang Shin-Ae ) - Yonsei University College of Medicine Department of Internal Medicine
박종숙 ( Park Jong-Suk ) - Yonsei University College of Medicine Department of Internal Medicine
안철우 ( Ahn Chul-Woo ) - Yonsei University College of Medicine Department of Internal Medicine
남지선 ( Nam Ji-Sun ) - Yonsei University College of Medicine Department of Internal Medicine
석정호 ( Seok Jeong-Ho ) - Yonsei University College of Medicine Department of Psychiatry

Abstract


Purpose: Little is known about the relationship between brain-derived neurotrophic factor (BDNF) gene polymorphisms and psychiatric symptoms in diabetes patients. We investigated the effects of BDNF Val/66/Met polymorphism, glucose status, psychological susceptibility, and resilience on anxiety and depression symptoms in patients newly diagnosed with type 2 diabetes mellitus (T2DM).

Materials and Methods: We examined biochemical factors and BDNF polymorphism in 89 patients who were newly diagnosed with T2DM. Psychiatric symptoms were investigated with the Hospital Anxiety and Depression Scale (HADS), and the Connor-Davidson Resilience Scale (CD-RISC) and Impact of Event Scale (IES) were used to assess psychological resilience and susceptibility to psychological distress, respectively. Logistic regression analyses were conducted to investigate factors associated with psychiatric symptoms.

Results: We determined that 62 patients (70%) were Met-carriers. No significant differences were found between the Val/Val homozygous and Met-carrier groups regarding age, sex, body mass index, and clinical factors related to glycemic control and lipid profiles. HADS-anxiety and HADS-depression scores and IES factor scores were higher in the Met-carrier than the Val/Val homozygous group. Hemoglobin A1c (HbA1c) level was significantly inversely correlated with the severity of depressive symptoms. Resilience factors showed significant inverse correlations, and IES factors showed positive correlations with depressive symptom severity. In the logistic regression analysis model, depressive symptoms were significantly associated with HbA1c and BDNF polymorphism, whereas only the hyperarousal factor of the IES scale was associated with anxiety.

Conclusion: Depressive symptoms are associated with the presence of the Met-carriers and lower HbA1c in patients newly diagnosed with T2DM.

키워드

Brain-derived neurotrophic factor (BDNF); polymorphism; diabetes mellitus; depression; anxiety

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