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Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea

Yonsei Medical Journal 2021년 62권 5호 p.417 ~ 423
김병기, 김수아, 김치영, 김유진, 이승현, 차재형, 김제형,
소속 상세정보
김병기 ( Kim Beong-Ki ) - Korea University Ansan Hospital Department of Internal Medicine
김수아 ( Kim Su-A ) - Korea University Ansan Hospital Department of Critical Care Medicine
김치영 ( Kim Chi-Young ) - Korea University Ansan Hospital Department of Internal Medicine
김유진 ( Kim Yu-Jin ) - Korea University Ansan Hospital Department of Internal Medicine
이승현 ( Lee Seung-Heon ) - Korea University Ansan Hospital Department of Internal Medicine
차재형 ( Cha Jae-Hyung ) - Korea University Ansan Hospital Medical Science Research Center
김제형 ( Kim Je-Hyeong ) - Korea University Ansan Hospital Department of Internal Medicine

Abstract


Purpose: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population.

Materials and Methods: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single university-affiliated hospital in Korea from September 1, 2018, to August 31, 2019. LIPS at the time of ICU admission and the development of ARDS were evaluated.

Results: Of the 548 enrolled patients, 33 (6.0%) fulfilled the Berlin ARDS definition. The LIPS for non-ARDS and ARDS groups were 4.96±3.05 and 8.53±2.45, respectively (p<0.001); it was significantly associated with ARDS development (odds ratio 1.48, 95% confidence interval, 1.29?1.69; p<0.001). LIPS >6 predicted the development of ARDS with a sensitivity of 84.8% and a specificity of 67.2% [area under the curve (AUC)=0.82]. A modified LIPS model adjusted for age and severity at ICU admission predicted ICU mortality in patients with ARDS (AUC=0.80), but not in those without ARDS (AUC=0.54).

Conclusion: LIPS predicted the development of ARDS as diagnosed by the Berlin definition in the Korean population. LIPS provides useful information for managing patients with ARDS.

키워드

Acute lung injury; respiratory distress syndrome; respiratory insufficiency; prediction model; critical illness

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