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벤지미다졸 유도체 투여 후 간흡충체표의 미세구조 관찰

The Ultrastructure of the Body Wall of Clonorchis sinensis after "Benzimidazole derivative" Treatment

Yonsei Reports on Tropical Medicine 1977년 8권 1호 p.1 ~ 4
소진탁, 민덕영,
소속 상세정보
소진탁 ( Soh Chin-Thack ) - Institute of Tropical Medicine Yonsei University
민덕영 ( Min Duk-Young ) - Yonsei University College of Medicine Department of Parasitology

Abstract


Micromorphological changes of the integument of the Clonorchis sinensis was examined after administration of a Benzimidazole derivative, Methyl N-[5-(6)-(p-fluorobenzoyl)-2-benzimidazolyl] carbamate, with the doses of 20^40 body weight mg/kg single dose, to the infected rabbits. In the treated group, plasma membrane was flatten and destroyed, mitochondria were disappeared, secretory granules were concentrated along the proximal Fortion of the integument and in epidermal cells. Protoplasmic tubules be-came clear by treatment and no content was recognized in the tubules at this phase. The connective tissue layer under the basement membrane became pale and disappeared.

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