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Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Korean Journal of Internal Medicine 2021년 36권 1호 p.175 ~ 181
하혜림, 김범석, 옥찬영, 김태민, 김진호, 정은재, 권성근, 안순현, 우홍균, 성병훈, 허대석,
소속 상세정보
하혜림 ( Ha Hye-Rim ) - Seoul National University Hospital Department of Internal Medicine
김범석 ( Keam Bhum-Suk ) - Seoul National University Hospital Department of Internal Medicine
옥찬영 ( Ock Chan-Young ) - Seoul National University Hospital Department of Internal Medicine
김태민 ( Kim Tae-MIn ) - Seoul National University Hospital Department of Internal Medicine
김진호 ( Kim Jin-Ho ) - Seoul National University Hospital Department of Radiation Oncology
정은재 ( Chung Eun-Jae ) - Seoul National University Hospital Department of Otorhinolaryngology
권성근 ( Kwon Seong-Keun ) - Seoul National University Hospital Department of Otorhinolaryngology
안순현 ( Ahn Soon-Hyun ) - Seoul National University Hospital Department of Otorhinolaryngology
우홍균 ( Wu Hong-Gyun ) - Seoul National University Hospital Department of Radiation Oncology
성병훈 ( Sung Myung-Whun ) - Seoul National University Hospital Department of Otorhinolaryngology
허대석 ( Heo Dae-Seog ) - Seoul National University Hospital Department of Internal Medicine

Abstract


Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC.

Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018.

Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached).

Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.

키워드

Carcinoma, adenoid cystic; Chemoradiotherapy; Cisplatin

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