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Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Korean Journal of Internal Medicine 2021년 36권 1호 p.205 ~ 213
고재훈, Woo Hyeong-Taek, 오홍상, 문송미, 최준영, 임정욱, 김동훈, 변준수, Kwon Soon-Hwan, 강대연, 허중연, 백경란,
소속 상세정보
고재훈 ( Ko Jae-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
 ( Woo Hyeong-Taek ) - Armed Forces Medical Command Department of Preventive Medicine
오홍상 ( Oh Hong-Sang ) - Armed Forces Capital Hospital Department of Internal Medicine
문송미 ( Moon Song-Mi ) - Seoul National University Bundang Hospital Department of Internal Medicine
최준영 ( Choi Joon-Young ) - Armed Forces Capital Hospital Department of Internal Medicine
임정욱 ( Lim Jeong-Uk ) - Armed Forces Capital Hospital Department of Internal Medicine
김동훈 ( Kim Dong-Hoon ) - Armed Forces Medical Command Department of Preventive Medicine
변준수 ( Byun Jun-Su ) - Armed Forces Medical Command Department of Preventive Medicine
 ( Kwon Soon-Hwan ) - Armed Forces Medical Research Institute Research Center for Infectious & Environmental Diseases Department of Infectious Diseases
강대연 ( Kang Dae-Youn ) - Armed Forces Medical Research Institute Research Center for Infectious & Environmental Diseases Department of Infectious Diseases
허중연 ( Heo Jung-Yeon ) - Ajou University School of Medicine Department of Infectious Diseases
백경란 ( Peck Kyong-Ran ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine

Abstract


Background/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter.

Methods: To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) results, pneumonia surveillance results, and severe HAdV cases from all 14 Korean military hospitals from January 2013 to May 2018 and compared these data with nationwide RV surveillance data for the civilian population.

Results: A total of 14,630 RV-PCRs was performed at military hospitals. HAdV (45.4%) was the most frequently detected RV, followed by human rhinovirus (12.3%) and influenza virus (6.3%). The percentage of the military positive for HAdV was significantly greater than the percentage of civilians positive for HAdV throughout the study period, with a large outbreak occurring during the winter to spring of 2014 to 2015. The outbreak continued until the end of the study, and non-seasonal detections increased over time. The reported number of pneumonia patients also increased during the outbreak. Case fatality rate was 0.075% overall but 15.6% in patients with respiratory failure. The proportion of severe patients did not change significantly during the study period.

Conclusions: A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.

키워드

Adenoviridae; Disease outbreaks; Korea; Military personnel; Type 55

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