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再生肝의 in vitro에 있어서의 蛋白合成과 Hormonal Factor

Studies on the Protein Synthesis of Regenerating Liver in Vitro, Concerning the Role of a Hormonal Factor

경북의대잡지 1968년 9권 2호 p.39 ~ 46
김종태,
소속 상세정보
김종태 (  ) - 경북대학교 의과대학 생화학교실

Abstract


In an effort to obtain evidence for or against the existence of humoral factor accelerating the protein synt hesis in remaining fragment of liver after partial hepatectomy, studies on the effect of liver regenerating rat blood on the protein synthesis oi´ normal or regenerating liver slices were carried out in vitro by measuring the incorporation rate of amino acid mixed-C^14 into liver protein.
Mitotic activity commenced after 24 hours and then proceeded rapidly to the maximum after 36 hours The rate of liver protein synthesis of regenerating liver was significantly increased at 20 .hours, and at 40 hours the rate showed about a 6-fold increase. In comparison of the synthetic rate of normal liver slice incubated in normal rat blood for 4 hours with those in the blood from hepatectomized rat (20 and 40 hours after hepat-ectomy), no noticeable difference was observed.
The protein syntheses of regenerating livers, ´ 20 and 40 hours after hepatectomy, were also not influenced by replacing the blood of liver regenerating :rats with normal rat blood. From the above experim~~rtal results, i~ is concluded that there is no evidence to support the existence of a postulate;d hurnoral factor in liver slice experiment.

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