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白鼠再生肝의 Lysosomal Acid Phosphatase에 關한 硏究

Studies on Lysosomal Acid Phosphatase in Regenerating Rat Livers

경북의대잡지 1969년 10권 2호 p.139 ~ 145
배종호, 柳虎烈,
소속 상세정보
배종호 (  ) - 慶北大學校 醫科大學 生化學敎室
柳虎烈 (  ) - 慶北大學校 醫科大學 生化學敎室

Abstract


Lysosomal and cytoplasmic acid phosphatase activities and osmotic fragility of Iysosome of regenerating rat livers after 70% (median and left lateral lobes) partial hepatectomy were studied.
After 6 hours of the operation, a littte increase in the activity of lysosomal form, per μg of liver nitrogen, was abserved, but no significant change on wet liver weight. A decrease, especially in the early stage of regeneration, took place in the liver nitrogen content. The enzymatic activity started to be on the decrease from the 14th hour, and showed a noticeable decrease after 3 days on both liver nitrogen and liver wet weight. The activities reached a near restoration after 5 days to he steady thereafter.
In contrast, cytoplasmic form showed not much difference on liver wet weight but a little increase on liver nitrogen, after 6 hours, A significant decrease was also noted after 1-3 days on liver wet weight.
Osmo ic fragility of lysosomes was calculated from unbound acid phosphatase activity by incubating lysosome preparations in 0.25, 0.15, 0.10 and 0.075 M sucrose for 40 min at 37℃. The fragility showed a significant decrease after partial hepatectomy and the values on 1-3 posthepatectomy days were about a half that of control rats.

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