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Incomplete Freund´s adjuvant 주입으로 인한 국소임파절의 반응

Stimulation of the Regional Lymph Node by Incomplete Freund´s Adjuvant

경북의대잡지 1970년 11권 2호 p.253 ~ 256
朴熙明, 김보완, 손상균, 이규보, 이영석,
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朴熙明 (  ) - 경북대학교 의과대학 병리학
김보완 (  ) - 경북대학교 의과대학 병리학
손상균 (  ) - 경북대학교 의과대학 병리학
이규보 (  ) - 경북대학교 의과대학 병리학
이영석 (  ) - 경북대학교 의과대학 병리학

Abstract


The experiment was carried out to ascertain the effect of incomplete Freund´s adjuvant to the lymph node.
Incomplete Freund´s adjuvant was injected subcutaneously into the dorsal foot-pad of the rabbit ana the draining popliteal lymph node was removed, 3, 7, 10, 15, and 20 days after the injection. The lymph nodes were examined histologically with hematoxylin-eosin and methylgreen-pyronin stainings. And following conclusions were obtained.
1. The regional lymph node shows marked proliferation, chiefly of "large pyroninophilic cells", with the injection of incomplete Freund´s adjuvant.
2. This proliferative response could be explained by the non-specific resonses due to the direct stimulation of the incomplete Freund´s adjuvant or by the specific responses due to the possible autoimmune mechanism induced by the degenerated tissue at the site of injection.

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