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흰쥐에 있어서 사염화탄소의 투여가 간장의 Amino산 대사에 미치는 영향

The Effect of Carbon Tetrachloride on the Amino Acid Metabolism of Liver in Rats

경북의대잡지 1971년 12권 1호 p.79 ~ 82
박상태,
소속 상세정보
박상태 (  ) - 경북대학교 의과대학 생화학교실

Abstract


This study was undertaken to evaluate the effects of carbon tetrachloride on the cellular transport of alpha-aminoisobutyric acid-1´C a~zd incorporation into proteins and conversion to ´~CO~ of amino acids mixed-1~C in rats.
Administration of carbon tetrachloride by means of stomach tube in fast caused a significa:at decrease of the cellular transport together with the decrease of the incorporation into protein .in liver. The incorporation also decreased in serum protein but showed no noticeable change in kidneyprotein.
The activities of expired ´~CO~ at varied intervals following the administration of amino acids mixed-1~C were not significantly altered by carbon tetrachloride poisoning.
From the experimental results, it is deduced that the decreasing effect of carbon tetrachloride on liver protein synthesis is due to the decrease of amino acid transport as well as the toxic effects on protein synthetic sites.

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