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Acid Phosphatase반응을 중심으로한 호중성 백혈구과립의 존재양상에 관한 전자현미경적 세포화학적 연구

Electron Microscopic and Cytochemical Study of Granules of Polymorphonuclear Leukocyte

경북의대잡지 1972년 13권 1호 p.1 ~ 12
최기선, 황선호,
소속 상세정보
최기선 (  ) - 경북대학교 의과대학 병리학교실
황선호 (  ) - 경북대학교 의과대학 병리학교실

Abstract


It is evident that neutrophils participate in an important-role in body defense mechanisms. The neutrophilic granules -lysosone- are thought as main machinery in the process of digestion cf phagocytized foreign materials. The polymorphonuclear leukocyte granules were investigated by examining developing granulocyte from n:;rmal rabbit bone marrow, in order to study how they exist, from where they are derived a;:.d how they develop. in additcn, acid phospho=_phatase activit}> was scored at electron microscpic level.
The results were:
Two distinct types of granules, azurophil a::d specific, were distinguished on the basis oftheir differences in size, density and time of origin. Both ypes originated from Golgi complex, but azurophil granules originated in the prcgranuloyte stage and specific granules originated in the myelocyte stage. Ko transforming features were found between the two types but azurophil granules decreased in number throughout successive maturation stages. Azurophil granules were more dense and larger than specific granules.
Acid phosphatase activity was found in both immature azurophil and specific granules, as well as cisternae of rEr and Golgi complex, but mature azurophil and ,specific granules did not eZhibit This activity.

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