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强制運動에 依한 胃出血에 있어서 그 負荷時間 및 反復負荷가 白鼠胃粘膜의 微細血管 및 肥滿細胞에 미치는 影響에 關한 實驗的 硏究

Changes of Mucosal Microcirculation and Submucosal Mast Cells in the Rat Stomach Exposed to Exertion Stress According to Its Duration and Times of Repetition

경북의대잡지 1972년 13권 2호 p.123 ~ 129
이보근,
소속 상세정보
이보근 ( Lee Bo-Kun ) - 경북대학교 의과대학 내과학교실

Abstract


Vascular changes and mast cell count of the mucosa of rat stomach were examined according to the duration of exertion stress and times of repetition of stress with days of rest intervals. Exertion stress was induced by the method desc;ibed by Robert et al, i. e. , forced muscular exercise ;by running the interior of, rotating drum for three periods of 45 min. :each seperated by two rest periods of 15 min. each as a fullcourse, and experimental groups weredevided into the following 5 groups. (1) 45 min. group: Group of rats .examined after exertion stress of 45 min. duration. (2) 90 min. group: Group of rats examined after´"two periods of 45 min. exertion stress with a period of rest of 15 min. in between. (3) 135 min. group: Group of rats examined after three .periods of 45 min. exertion stress each seperated .by two- rest- periods ~f I5 min. each (a full course). (4) 135 min. x 2 group: Group of rats examined after repeated exertion stress of two full courses of stres with a 3 days of rest interval in between. (5) 135 min. x 3 group: Group of rats examined after repeated exertion stre:;s of three full courses of stress with a 3 days of rest interval between each. The results of the study can be summarized as follows: 1. Macroscopic mucosal hemorrhage of the stomach was most marked in 135 ruin. group and it became less marked in repeated stress groups of 135 min, x 2 and 135 min. x 3 groups. 2. Microscopic vascular engorgeme~its of the gastric mucosa parallels roughly to i;he degree of macroscopic hemorrhage, that is, it .wasmost marked in 135 min. group and became less marked in repeated stress groups of 135 min. x 2 and 135 min. x 3 groups.
3. Mast cell count of submucosa of the stomach decreased to the lowest level in 45 min. group and did not change further by prolongation of the stress (i. e. in 90 and 135 min. groups) or repetition of the stress (i. e. in 135 min. x 2 and x 3 groups). 4. The above results suggest that macroscopic mucosal hemorrhage or microscopic vascular engorgement of the gastric mucosa is not necessarily related to the changes of the mast cells in the gastric submucosa. In other words, mucosal hemorrhage and vascular engorgement can be influenced by other or additional factors than mast cell degranulation.

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