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Peroxidase 반응을 중심으로 한 호중성 백혈구과립의 존재양상에 관한 전자현미경적 세포화학적 연구

Peroxidase Activity of Granules of Polymorphonuclear Leukocytes on the Electron Microscopic Level

경북의대잡지 1972년 13권 2호 p.147 ~ 155
최병영, 황선호,
소속 상세정보
최병영 (  ) - 경북대학교 의과대학 병리학교실
황선호 (  ) - 경북대학교 의과대학 병리학교실

Abstract


It is evident that neutrophils participate in an important role in body defense mechanisms.
The neutrophilic granules -lysosome- are thought as main machinery in the processes of digestion of phagacytized foreign materials. The polymorphonuclear leukocyte granules were investi-gated by examining developing granulocyte from normal rabbit bone marrow, in order to study how they exist, from where they are derived and how they develop. In addition, peroxidase activity was scored - at electron microscopic level.
The results were:
Two distinct types of granules, azurophil and specific, were distinguished on the bases of their differences in size, density and time of origin. Both types originated from Golgi complex, but azurophil granules originated in the progranulocyte stage and specific granules originated in the myelocyte stage. No transforming features were found between the two types. The azurophil granules decreased in number throughout successive maturation stages. Azurophil granules were more dense and larger than specific granules.
Peroxidase activity was found in both immature and mature azurophil granules but specific granules and lumen of rER and Golgi complex failed to demonstrate the peroxidase activity.
Reaction patterns were different in individual azurophil granules which suggested heterogeneity of the granues.

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