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Adenin이 Ethionine으로 야기된 간세포 상해의 회복에 미치는 영향에 관한 전자현미경적 연구

Electron Microscopic Observation of Reversibility of Ethionine Induced Liver Cell Injury by Adenine

경북의대잡지 1972년 13권 2호 p.157 ~ 169
김형곤, 황선호,
소속 상세정보
김형곤 (  ) - 경북대학교 의과대학 병리학교실
황선호 (  ) - 경북대학교 의과대학 병리학교실

Abstract


There are many reports about the hepatotosicity of thionine and the reversibilit}r of the injury by methionine, adenine, inosine; and so on. Ethionine induces degenerative changes of the liver cell nucleus and various cytoplasmic organells for which adenine may reverse and proven*. such alterations of them. The purpose of this observation is to review the alterations of c toplasmic organelle and nucleus and to atte~ip to study the relationship between structural and biochemical changes of hepatic cells, especially of those structures related to the lysosomes.
DL-Ethionine (1 mg/ gm of body weight) vas injected intraperitoneally to 24 rats and adenine sulfate (32mg) was rsinjected intraperitoneaily to the half of them 6hrs after initial injection. Control groups were received saline only, e~hionine and saline, or saline and aden ine respectively. Each group of animals vas killed at 3, 6, 9 and 12 ham´ after -the lastinjection respectively and the livers were taken. from the rats. Sections of the tissue ,vere observed under the light and election microscopee:
The liver cells showed slight cloudy swelling in early time and progresssively severer in later time, but milder in adenine treated group. On the electron microscopical levels, liver cells showed dilatation of endoplasmic reticulum, shedding of ribosome, swelling and partial disruption of mitochondria, and increase of various types of the lysosomes. Most of the lysosomes in early stage were primary type but changed to secondary type in later time. Adenine in jection induced production of new primary lysosome and recovering of the alterations of cytoplasmic organells. The results suggest that adenine can reverse ethionine induced alterations of the organells but already injured organells go on destruction by newly formed lysosomes.

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