Prednisolone이 淋巴組織에 미치는 影響에 關한 病理組織學的 硏究
Effects of Prednisolone on Lymphoid Tissues of the Adult Rabbit
경북의대잡지 1973년 14권 2호 p.303 ~ 315
강신학, 洪錫宰,
소속 상세정보
강신학 ( ) - 경북대학교 의과대학 병리학교실
洪錫宰 ( ) - 慶北大學校 醫科大學 病理學敎室
KMID : 0351619730140020303
Abstract
著者는 成熟家?를 實驗ㄴㄴ動物로 하여 prednisolone을 小量 乃至 大量 投與하고, 蟲垂의 淋巴組織, 腸間膜 淋巴節, 脾小體 및 胸線에 惹起되는 變化를 機能的 組織構造에 따라 分析的으로 檢索하여 다음과 같은 結果를 얻었다.
1) 腸關連 淋巴組織 특히 蟲垂의 淋巴組織에서 Waksman등이 主張한 機能적 組織構造로서의 dome, corona,follicle,thymus-dependent area (TDA)등을 確認할 수 있었다.
2) Prednisolone을 投與한 家?의 蟲垂 淋巴組織에 있어서는 dome에서 大淋巴絶球와 淋巴母細胞 및 小淋巴絶球의 顯著한 減少와 大食細胞의 著明한 增加를, corona에서는 小淋巴球의 甚한 消失과 大食細胞의 顯著한 增加를 그리고 follicle에서는 大淋巴球, 淋巴母細胞 및 小淋巴球의 甚한 消失과 大食細胞의 顯著한 增加를 볼수 있었으나 TDA에서는 小淋巴球 및 淋巴母細胞가 極히 輕한 程度로 減少하였을 뿐으로서 거의 正常한 狀態가 維持되었다.
3) 腸間膜淋巴節에 있어서는 淋巴小節의 種中心에서 大淋巴球와 淋巴母細胞의 甚한 消失과 細綱細胞의 著明한 增加를 볼 수 있었으며. TDA에서는 小淋巴球의 輕한 減少가 있을 뿐 뚜렷한 變化를 認定할 수 없었으며, 髓質에서는 大淋巴球가 顯著하게 增加하고 細胞分裂像도 處處에서 認定되었다.
4) 脾小體에 있어서는 種中心에서 大淋巴球와 淋巴母細胞의 顯著한 減少와 細綱細胞의 增加를 볼 수 있었고, 小體周?帶에서는 小淋巴球의 輕度減少가 認定되었다.
5) 胸線에 있어서는 小葉皮質에서 淋巴球의 甚한 消失과 細綱細胞의 顯著한 增加를 볼 수 있었으나 髓質에서는 淋巴球가 거의 減少되지 않고 正常한 狀態가 維持되었다.
6) Prednisolone을 投與한 家?의 여러 淋巴組織에서 惹起된 上記한 바와 같은 變化들은 Prednisolone의 投與量을 增加함에 따라 더욱 顯著하였다.
7) 以上의 實驗性的으로 보아 corticosteroid를 家?에 投與할 때에는 蟲垂에 있어서 B淋巴球의 産生處인 dome과 增殖處인 follicle이 主로 甚하게 侵害되고 T淋巴球가 存在하는 TDA는 別로 損傷을 받지 않으며, 腸間膜淋巴節과 脾小體에 있어서는 種中心의 細胞들이 主로 侵害되고, 역시 TDA에 該當하는 組織은 損傷을 적게 받으며, 胸線에서는 皮質의 淋巴球가 主로 甚하게 侵害되고 髓質의 淋巴球는 別로 損傷을 받지 않는 것으로 推定된다.
This study was undertaken to investigate the changes of functional histologic structures in the lymphoid tissues of the adult rabbit treated with prednisolone.
Fifteen healthy rabbits, weighing 2 to 2.5kg were divided into 4 groups:
Group 1. Control group three rabbits: Untreated.
Group 2. Four rabbits: A dose of 5mg of prednisolone was given intramuscularly for 3 consecutive days.
Group 3. Four rabtits: A dose of 10mg of prednisolone was given intramuscularly for 3 consecutive days.
Group 4. Four rabbits: A dose of 20mg of prednisolone was given intramuscularly for 3 consecutive days.
Each of the experimental rabbits were sacrificed 24 hours after the last treatment of prednisolone from the group 2, 3 and 4. Then the appendix, mesenteric lymph node, spleen and thymus were extirpated and examined histologically.
The results were as follows:
1) The author also was able to recognize the distinction of the functional histologic structures in the lymphoid tissue of the appendix, a dome with attached corona, a follicle and a thymusdependent area (TDA) as Waksman et al had already emphasized.
2) In the appendix of the rabbits treated with prednisolone, marked loss of large and small lymphocytes as well as marked increase of the phagocytes were noted. In the thymf-dependent area, there was a very mild decrease of the lymphocytes and the normal tissue pattern was relatively well preserved.
3) In the mesenteric lymph node, marked loss of the large lymphocytes and blasts and a remarkable increase of the reticulum cells in the germinal center were observed. It was also noted that there was only a very ugnoticeable decrease of the lymphocytes in the thymus-dependent area. in the medullary portion there was a marked increase of the large lymphocytes and some mitotic figures were also seen.
4) In the splenic corpuscle marked loss of the large lymphocytes and some increase of the reticulum cells in the germinal center were noted. In the peripheral portion of the follicle there was only a mild decrease of the small lymphocytes.
5) In the thymus severe loss of the cortical lymphocytes and remarkable increase of the reticular cells were observed. In the medulla of the lobule however, there was no decrease of the lymphocytes, maintaining an almost normal cellular pattern.
6) The above mentioned changes occurred in the lymphoid tissues of the rabbits treated with prednisolone were quite parallel with the dosage given.
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