Glucagon이 胃液分泌에 미치는 影響에 關하여
Effect of Glucagon on Gastric Secretion
경북의대잡지 1973년 14권 2호 p.317 ~ 326
조세환, 洪善熹,
소속 상세정보
조세환 ( )
慶北大學校 醫科大學 外科學敎室
洪善熹 ( )
慶北大學校 醫科大學 外科學敎室
KMID : 0351619730140020317
Abstract
Glucagon이 histamine에 대한 胃液分泌反應에 미치는 影響을 觀察하기 위하여 13마리의 雜種成犬을 Pavlov pouch群(6마리)과 Heidenhain pouch群(7마리)으로 나누어 histamine을 皮下 또는 持續靜注하여 胃液分泌를 刺戟한 狀態에서 glucagon을 靜注하여 胃液分泌量, 遊雛酸度, 血糖 및 血淸 calcium値를 測定한 結果를 要約하면 다음과 같다.
Histidine投與로 顯著하게 增加된 胃液分泌量과 遊雛酸度는 glucagon投與로서 減少하는 傾向이 있었으나 全體的으로 보아 有意한 것은 아니였으며 Paviov pouch群과 Heidenhain pouch群과의 差異는 볼 수 없었다.
Gulcagon投與로서 血糖量이 增加하였을 때 胃液分泌가 減少하였으나 血糖量 增加와 胃液分泌減少는 比例하지 않았던 것으로 보아 血糖量 增加가 胃液分泌抑制의 直接的 要因은 아니라고 生覺되며 Paviov pouch群과 Heidenhain pouch群 사이에 特別한 差異가 없었든 事實은 胃液分泌抑制가 迷走神經作用에 起因하는 것이 아님을 推測케 하였다.
Glucagon投與는 血淸 calcium濃度에 影響을 주지 않았으며 glucagon에 의한 胃液分泌抑制는 血淸calciumr과 關係가 없는 것으로 生覺되었다.
Glucagon, the hyperglycemic glycogenolytic hormone, has been shown to inhibit the basal secretion, acid output and secretion induced by meals, sham feeding, insulin, gastrin and distention of the pyloric antrum both in man and in the experimental animal. However, the precise mechanism of its inhibitory action on gastric secretion is unclear and the effect on histamine induced gastric secretion is controversial.
In addition, glucagon has been known to decrease the concentration of serum calcium and it might be speculated that lowered serum calcium level plays a role to suppress the gastric secretion.
This experiment was undertaken to observe the effects of glucagon on histamine stimulated gastric secretion and the concentration of serum calcium in the dog.
The experiments were performed on seven denervated Heidenain pouch and six innervated Pavlov pouch dogs.
In one experimental group, glucagon was given continuously intraveneously for an hour after subcutanous injection of histamine twice at 30 minutes interval In the other, same administration of glucagon was done two hours after the initiation of continuous infusion of histamine which was continued for three hours.
Gastric juice was collected for every 30 minutes and the gastric secretory rate and acid output were measured. Blood sugar and serum calcium were determined every half an hour.
The following results were obtained:
1. After the administeration of glucagon, marked hyperglycemia was observed and the gastric secretory rate and acid output were considerably reduced in both Heidenhain and Pavlov pouch dogs, however, there was no parallelism between the increase in blood sugar and the reduction of gastric secretion.
2. No significant difference between innervated and denervated pouch dogs in an inhibitory effect on gastric secretion was noted.
3. The concentration of serum calcium was not changed by glucagon.
4. As a result, it is suggested that hypergloycemia or serum calcium level is not a primary factor and vagal nerve is not involved in an inhibition of gastric secretion which was induced by glucagon.
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