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사염화탄소 유발 흰쥐 경변간의 핵산 및 단백합성에 관하여

Synthesis of Protein and RNA of Carbon Tetrachloride Induced Cirrhotic Liver in Rats

경북의대잡지 1973년 14권 2호 p.345 ~ 348
이진식, 申鉉洙,
소속 상세정보
이진식 (  ) - 경북대학교 의과대학 생화학교실
申鉉洙 (  ) - 경북대학교 의과대학 생화학교실

Abstract


The present study was to observe the change in RNA and protein metabolism of the carbon tetrachloride induced cirrhotic liver in rats.
Sprague-Dowley rats were injected subcutaneously twice weekly with a 50% solution of carbon tetrachloride in olive oil for 13 weeks. Twenty rats developed severe cirrhosis of the liver were divided to two group and injected with L-lysine-^(14)C and orotic acid-^(14)C for the measurement of the incorporations.
The incorporation of L-lysine-^(14)C into liver protein decreased by 33% and that of orotic acid-^(14)C into total and nuclear RNA was reduced by 43% and 48% respectively in carbon tetrachloride induced cirrhotic liver.
The above result demonstrated that the RNA synthesis was more significantly decreased than protein synthesis in cirrhotic liver induced by a long term administration of carbon tetrachloride.

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