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Steady State Hypoxia의 심맥관계 및 호흡반응

Cardio-pulmonary Responses to Steady State Hypoxia

경북의대잡지 1974년 15권 1호 p.23 ~ 30
문정숙, 이원길, 허도주,
소속 상세정보
문정숙 (  ) - 경북대학교 의과대학 생리학교실
이원길 (  ) - 경북대학교 의과대학 생리학교실
허도주 (  ) - 경북대학교 의과대학 생리학교실

Abstract


In order to observe an adaptation process of living body to hypoxia, cardio-pulmonary changes were observed for 50 mi ~:aes in moderate hypoxia.
Hypoxia was induced by inhalation of a gas mixture with 12 0 0~ and 88 o N~ gas. Experimental animals were 18 adult mongrel dogs having average weight of 1? k,. Animals were anesthetized with the thiopental sodium.
10 animals were observed with continuous and simultaneous records of heart rate, blood pressure, central venous pressure and respiration rate, and the other 8 animals were measured for oxygen consumption, tidal volume, minute ventilation, respiration rate at 15 to 20 minutes, 35 to 40 minutes. and 45 to 50 minutes after inhalation of low oxygen gas mixture.
The measurements in hypoxia was comparedwith the control data obtained in the room air.
Heart rate was maintained higher until 30 minutes a;`ter exposure to hyp^sia l;ut it returned almost to the normal cortro at 50 minutes. Blued pressure was gracuaii~,- decreased. Central vE;nous pressure sho~~-,e~ no changes. Respiration rate was maintained higher until 30 minutes but returned to the cur_*col value at 50 minutes. Oxygen consumption a:i ~idal volume: were gradually decreased. From above results the better compensation to moderate hypoxia as the steady state hypoxia was demonstrated.
Despite of minimum changes of respiratory responses, general cardio-pulmonary functions were assurzed to be regulated properly except a tendency of decreasing blood pressure that was a specific phenomenon in stcad~* state hypoxia.

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