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Sodium Fluoride(NaF)의 Rat 摘出心房收縮 亢進作用에 미치는 Ca^(++)의 影響

Mode of Positive Inotropic Action of Sodium Fluoride on the Rat´s Isolated Atira especially in relation to Calcium

경북의대잡지 1974년 15권 1호 p.53 ~ 56
김중영, 朴震洪, 李秀淵,
소속 상세정보
김중영 (  ) - 慶北大學校 醫科大學 藥理學敎室
朴震洪 (  ) - 慶北大學校 醫科大學 藥理學敎室
李秀淵 (  ) - 慶北大學校 醫科大學 藥理學敎室

Abstract


The present experiments were undertaken to observe changes on sodium fluoride-induced positive inotrepic action- of isolated rat atira following the reduction of calciur~~. concentration in bathing media, modified Krebs Ringer Buffer solution.
1. Negative effects of lowering the media calcium concentration on isotropic action of isolated rat´s atria were almost the same magnitude in both modified Krebs Ringer Suffered solution with glucose and that with glucose plus py;ruvate.
2. The lowering of media caicium concentration suppressed. NaF-induced positive isotropic action i:n modified Krebs Ringer buffer solu ties with glucose, but not in the solution with glucose plus pyruvate.
It is likel;g to indicate that NaF-induced positive inotropie action is more related to metaboli~~-m or transport of substrate in the media than to etiogenous calciun. concentration.

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