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X線 全身照射가 家兎 淋巴組織에 미치는 影響에 關한 病理組織學的 硏究

Effects of Whole Body X-Irradiation on Functional Histologic Structures of Lymphoid Tissues in the Rabbit

경북의대잡지 1974년 15권 1호 p.189 ~ 205
민병훈, 홍석재,
소속 상세정보
민병훈 (  ) - 경북대학교 의과대학 병리학교실
홍석재 (  ) - 경북대학교 의과대학 병리학교실

Abstract


This study was undertaken to investigate the effects of x-irradiation on the furcinal Mitologic structures of lymphoid tissus of the adult rabbit.
Eighteen healthy rabbits, weighing 2 to 2.5kg, were divided into 2 groups:
Group 1. .Control group: Untreated (3 rabbits).
Group 2. Experimental group: A single air dose of 600r whole body x-irradiation ~,~as liven ~ 15 rabbits). Experimental animals were sacrificed after 30 minutes, 3 hours, 6 hours, 1 day and 3 days respectively. Then the appendix, mesenteric lymph rode, s~l~n and thymus were extir-pated and examined histologically.
The results were as follows:
1) In the appendix marked necrotic loss of sma1T and large lymphocytse as well as considerable increase of macrophages were noted at the dome, .corona and folli~~le, while necrotic loss of lymphocytes were milder at the thymus-dependent area (TDA). These changes were milder after 30 minutes and increasingly severer during 3 hours to 1 day. After 3 days lymphocytes were markedly increased in r_umber at the dome and corona.
2) In the mesenteric lympl´i nodes, marked necrotic loss of large and small lymphocytes as well as marked increase of macrophages were noted at the lymph follicle and medullary cords, but TDA showed milder changes.
3) In the spleen, peripheral area of the splenic corpuscle showed marked necrotic loss of large and small lymphocytes as well as increase of macrophages. Ini the periarteriolar area, which corresponds to TDA, lymphocytes were relatively well preserved in. spite of some degree of necrotic loss of the cells.
4) In the thymus, significant number of lymphocytes were necrotized and Tossed at the cortical area, but these changes were relatively milder in the medullary area. IVlarked increase of macrophages were accompanied necrosis of lymohocytes. These changes were mild at 30 minutes and increasingly severer to reach to the maximum at the 3 days.
5) According to the above mentioned changes, the following suggetion could be made. X-irradiation induced early damage of the central lymphoid tissue which produces B-lymphocytes but it showed early recovery from the damages. The damaging effects to the central lymphoid tissue which prod-uces T-lympocytes appeared at later time. In the peripheral lymphoid tissues, B-lymphocytes were more severely damaged and T-lymphocytes were relatively mildly damaged.

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