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Ethanol의 低溫心臟에 對한 抗細動作用에 關한 硏究

The Antifibrillatory Effects of Ethanol on the Hypothermic Heart of the Dogs

경북의대잡지 1974년 15권 1호 p.253 ~ 261
박연열, 李聖行,
소속 상세정보
박연열 (  ) - 경북대학교 의과대학 흉부외과학교실
李聖行 (  ) - 경북대학교 의과대학 흉부외과학교실

Abstract


This experimental study was performed to clarify the antifibrillatory e;fects of intravenous in-fusion of ethanol upon hypothermic hearts. Thirty six mongrel dogs were anesthetized with thiopental sodium and were ventilated with mechanical respirator throughout the experiment. Ethanol, 2.Og/kg, diluted with 5% dextrose solutior. `vas intravenously administe ed in divided doses for the expermental dogs and same amount of 5 % dextrose solution for control dogs. Animals wire cooled with ice water and rewarmed with hot water. Heart rates and cardiac arrhythr,_ia w~:re checked by ECG. Central venous pressure, right ventricular ant pulmonary arterial pressures were measured by means of cardiac catheterization.
Animals were divided into two groups.
Group 1.
Twenty dogs were cooled until death. Ar~icrg those, 10 cxperin.ental dc,s were infused ethanol intravenously.
Group 3.
Sixteen dogs were cooled down to body temperature of 20C, when cardiac inf)a;i- and ouiflow were occluded for the period of 15 minutes. Thea rewarmed the animals. The results were as follows.
1. Heart rates, arterial pressure, right ventricular and pulmonary arterial pressures were markedly decreased during the period. of cooling. Ethanol infusion showed no significant ir_fl:zence upon those decreases.
2. Central venous pressure increased to the Level of right heart failure of the cocIec animal, and ethanol revealed ~o protective action on cardiac impainent.
3. In group i, 10% of ventricular fibrillation was seen among the ethanol infused dogs while 30~ of ventricular. fibrilltion among the control group. In group 2, there was no significant difference of ventricular fibrillation between ethanol and control groups.
4. Ethanol blood level at 20C of body temperature was 636mg%.
5. It was suspected that ethanol failed to protect f:he hypothermic heart from ventricular fibrillation when cardiac inflow were occluded far the 15 minutes of period.

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