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平滑筋의 收縮機轉에 있어서의 Calcium의 關聯에 對하여

Mechanism of the Smooth Muscle Contraction, in Relation to Calcium

경북의대잡지 1974년 15권 2호 p.77 ~ 83
이수연, 徐大圭,
소속 상세정보
이수연 (  ) - 慶北大學校 醫科大學 藥理學敎室
徐大圭 (  ) - 慶北大學校 醫科大學 藥理學敎室

Abstract


Using the strips of rabbit´s vas deferens, the mechanism of the smooth muscle contraction by potassium (K). acetylcholine (ACh) and barum (Ba) were investigated. From the effects of mtetabolic inhibition, such as anoxia and dinitrophenol (DNP), and calcium removal from the bath soution on the contraction curves, the following presumptions have been obtained:
1. The contraction cuves of K, ACh and Ba consisted of the phasic contraction(PC) and the subsequent tonic contraction (TC).
2. In the contractions of K and ACh, PC is produced by calcium release, while TC is maintained by energy-dependent influx of calcium.
3. In the case of Ba, the small residual contraction remains constant in the calcium-free bath solution, it is assumed that the direct action on the muscle contractile system without the mediation of calcium mobilization is also concerned part1y with the contracting mechanism.
4. The calcium stores in the muscle cell membrane are distinguished into the one where calcium is relatively easily released and one where calcium is not easily released, and K and ACh release calcium from the former store, while Ba does so from both the former and the latter stores.

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