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취장선방세포에 있어서 분비과정에 수반되는 Cytocavitary Network의 변화에 대하여

On the Changes of Cytocavitary Network during Secretory Cycle in the Pancreatic Acinar Cells

경북의대잡지 1974년 15권 2호 p.85 ~ 97
강영모, 김홍태,
소속 상세정보
강영모 (  ) - 경북대학교 의과대학 병리학
김홍태 (  ) - 경북대학교 의과대학 병리학

Abstract


This study was carried out to investigate the morphologic changes and interrelationship between cytocavitary networks of Arstila during secretory cycle in the pancreatic acinar cells. Twenty seven albino rats were injected 6mg of pilocarpine hydrochloride solution per 100gm of body weights, intramuscularly after 2days-NPO for synchronization. Each group of 3 animals was sacrificed at 1,2,3,4,5,6,7,8 and 10 hous after single pilocarpine injection. The pancreases were extirpated out and observed under electron microscope.
The results were summarized as follow :
All of the cytocavitary networks were influenced from the first hour after pilocarpine injection.
Intracisternal granules were not seen in the control group, but began to appear 2 to 3 hours, most abundantly 4 hours and disappeared 7 hours after the injection.
Vesicular changes of rER began to appear one hour and most typically after 2 to 3 hours. Vocuolization of rER appeared 4 hours and rER was changed to flattened sac 7 to 8 hours after pilocarpine injection.
As the results of above experiments, the orders of the changes in the cytocavitary network after pilocarpine injection were initially rER, next Golgi apparatus and then zymogen granules.
It is considered that the appearance of the intracisternal granules is rather the result of damage in the process of transportation of excretory protein to the Golgi apparatus than the result of increased secretory activity of the cell.
In this process, the life span of exportable protein is believed to be one hour and the total duration in a cycle from the excretion and synthesis of exportable protein to the reaccumulation of the protein in the cell is thought to be about 10 hours.

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