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Effects of Submaxillary Gland Extirpation on Functional Histologic Structures of Lymphoid Organs

경북의대잡지 1974년 15권 2호 p.99 ~ 116
강창수, 洪錫宰,
소속 상세정보
강창수 (  ) - 경북대학교 의과대학 병리학교실
洪錫宰 (  ) - 慶北大學校 醫科大學 病理學敎室

Abstract


This study was carried out to investigate the effects of the submaxillary gland extirpation on the functional histologic structures of the lymphoid tissue from adult rats and rabbits.
Fifteen albino rats, weighing 110-170gm, and twenty one rabbits, weighing 1,800-2,100gm, all maintained on a stock diet and divided into 3 experimental groups.
Group 1. Control Group.
a. 3 rats, untreated.
b. 3 rabbits, untreated.
Group 2. Submaxillary gland extirpation group.
a. 6 rats: Both submaxillary glands were extirpated.
b. 9 rabbits: Both submaxillary glands were extirpated.
Group 3. Sham operation group.
a. 6 rats: No submaxillary gland extirpation were carried out even though anesthesia and incisions were made as in group 2.
b. 9 rats: No submaxillary gland extirpation were carried out although anesthesia and incisions were made as in group 2.
Three each of the experimental rats were sacrificed 1 and 2 weeks after the pertinent treatment as described above(group 2a and 3a). Three each of the experimental rabbits were sacrificed 1,2 and 3 weeks after the pertinent treatment as described above (group 2b and 3b) One each of the control animals were sacrificed 1,2 and 3 weeks after the start of the experiment (group la and lb). After each animal sacrifice the thymus, appendix, mesenteric lymph nodes and spleen were taken out and examined under a light microscope to determine the effect of submaxillary gland extirpation on the functional histologic structures of the lymphoid organs.
The results were as follows;
1. Body weight and weight of the thymus, mesenteric lymph nodes, appendix and spleen of the experimental rats were found to be signiicantly decreased in rats in group 2a, 1 and 2 weeks after extirpation of the submaxillary glands whereas no discernible change of the body weight of the lymphoid organs noted in rabbits in group 2b.
2. Thymus: A considerable decrease in the number of the lymphocytes was noted in the cortex of the thymus of the experimental rats (group 2a). No such change was noted in the number of the lymphocytes of the rabbits(group 2b).
3. Appendiceal lymphoid tissue: No change was noted in the number of lymphocytes of the dome, corona, follicle and TDA of the experimental rabbits (group 2b). Rats do not have appendix, limiting further study.
4. Mesenteric lymph nodes: A marked decrease in the number of large and small lymphocytes of the lymph follicles medullary cords and TDA of the mesenteric lymph nodes of the experimental rats (group 2a) occured. No such numerical change was noted in the rabbit mesenteric lymph nodes (group 2b).
5. Splenic corpuscles: Considerable decrease in the number of large and small lymphocytes of the lymph follicles and TDA of the splenic corpuscles cf the experimental rats (group 2a) was noted whereas no such numerical change was found in the rabbits (group 2b).
It is therefore concluded that lymphoid organ of the rats are influenced greatly by submaxillary glands functionally while that of rabbits are not subjected to the same influence.

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