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흰쥐에 있어서 단즙울대시 肝의 Alkaling Phosphatase와 蛋白合成能의 變動에 關하여

Alkaling Phosphatase and Protein synthesis of Cholestatic Liver in Rats

경북의대잡지 1974년 15권 2호 p.147 ~ 154
김홍웅, 柳虎烈,
소속 상세정보
김홍웅 (  ) - 慶北大學校 醫科大學 生化學敎室
柳虎烈 (  ) - 慶北大學校 醫科大學 生化學敎室

Abstract


Hepatic and serum alkaline phosphatase activity and liver protein synthesis were studied in rats after total and partial ligation of bile duct.
Ligation of common bile duct lead to a rapid increase of serum bilirubin and serum alkaline phosphatase, and more rapid increase of hepatic alkaline phosphatase. Hepatic alkaline phosphatase increased 7 fold after 12 hours, whereas serum alkaline phosphatase 3 fold after 24 hours the ligation.
Partial ligation of bile duct; bile ducts of median and left lateral lobes, also induced a significant increase of serum alkaline phosphatase, but serum bilirubin level remained within normal after the ligation. Hepatic alkaline phosphatase afte the partial ligation, not only in ligated lobe but in unligated lobe, though the degree was less significant than ligated lobe, also showed a marked increase than serum alkaline phosphatase.
Serum glutamic pyravic transaminase had strikingly increased after total ligation of bile duct but the increase was greatly diminished in partial1y ligated rats.
Incorporation of amino acid mixed-^(14)C into liver protein was significantly increased in rats after ligation of common bile duct. In partial ligation, the incorporation showed a slight increase in ligated lobe compared to unligated lobe.

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