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腸티브스菌에 對한 chloramphenicol, nalidixic acid 및 trimethoprime 과 sulfamethoxazole의 協同作用

Combined actions of chloramphenicol with trimethoprime plus sulfamethoxazole and with nalidixic acid against Salmonella typhi

경북의대잡지 1975년 16권 2호 p.56 ~ 62
김정훈, 鄭在奎,
소속 상세정보
김정훈 (  ) - 慶北大學校 醫科大學 細菌學校室
鄭在奎 (  ) - 慶北大學校 醫科大學 細菌學校室

Abstract


For t:he purpose to observe the effects of chloramphenicol (Cb1) in combination with synthetic drugs such as nalidixic acid(NA) and trimethoprim(T) plus :>ulfa-methoxazole(S) a;ainst S. typhi,´´ in vitro experiments were carried out with 4 CM resistant and 2 standard strains.
Bacteriostatic actions were indifferent when CM was combined with T-S but bactericidal acions were inapparent as single bactericidal action of T-S was unable to determine. Combined actions´ of CM with NA were antagonic but CM resistant strains were highly sensitive to NA singleIy.. Minimum inhibitory actions were additive or synergistic when NA was combined with T-S bu bactericidal actions were antagonic.
when growth inhibition tests were performed by sub-minimum inhibitory concentrations wit above three kinds of drug combination, S. typl:i T~ strain exhibited additive or synergistic results, whereas S. typhi D25 isolated strain showed indifferent or additive findings.

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