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pH6.5에서 Sodium Fluoride 및 sodium Bicarbonate가 Halothane에 依하여 惹起되는 Negative Inotropic Action에 미치는 影響

The Effect of Sodium Fluoride and Sodium Bicarbonate on Halothane-induced Negative Inotropic Action at pH6.5

경북의대잡지 1975년 16권 2호 p.95 ~ 98
김중영,
소속 상세정보
김중영 (  ) - 경북대학교 의과대학 약리학교실

Abstract


The effects of sodium fluoride(NaF:l mM) and sodium bicarbonate(NaHCO3 : 22.8m~1) on the contractility of the electrically driven isolated rat atria in Kreb´s Ringer bicarbonate solution with or without halothane(4.5mg0.8%) were investigated in such condition as an inhibition of glycolysis as well as increase in permeability of dicarboxylic acid to cell membrane resulted from a lowering pH to 6.5, or glycolysis normally evoked, pH 7.4,
1. Decrease in contractility of isolated rat atria resulted ~`rom a lowering pH to 6.5 was overcome by added NaHCOa but the conquest was weakened by the i~resence of halothane.
2. Increase in contractility caused by added NaF was depressed in the presence of halothan at pH 6.5 but was not hindered by halothane at pH 7.4.
These results suggest under remaining further studies th;it decrease in contrcactility caused by halothane presence is related not only to inhibit to glycolysis but also to inhibit to the other metabolism.

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