內臟血管 結紮이 循環 Acid Phosphatase 및 肝細胞의 微細構造 變化에 미치는 影響
Effect of Splanchnic Artery Occlusion Induced Shock on the Lymph wnd Serum Acid Phosphatase Activity and Ultrastructural Changes of tho Hepatocyte of Dogs
경북의대잡지 1976년 17권 2호 p.153 ~ 164
이영하, 黃一愚,
소속 상세정보
이영하 ( ) - 慶北大學校 醫科大學 外科學敎室
黃一愚 ( ) - 慶北大學校 醫科大學 外科學敎室
KMID : 0351619760170020153
Abstract
This experiment was attempted to study the effect of splanchnic arteril occlusion (SAO) shock on the ultrastructural changes of the hepatocyte, the alerration of flow rate of thoracic duct lymph and the activity of serum and lymph acid phosphatase.
SAO shock was indueed by releasing the clamp after two hours occlusion of the splanchnic arterics in the experimental dogs.
Shortly after release of the occlusion, the mean arterial pressure feil to 60 mmHg, the flow of thoracic lymph inerased markedly, the blood pH decresed and the activity of lymph and serum acid phosphatase increased significantly.
The ultrastructure of the hepatocyte of SAO shock revealed degencrative changes characterized primarily by an apparent inercase in the number of secondary and post-lysosomes with vesiculation, vacuolation, fragmentation an ribosomal shedding of rER. Futhermore, degenerative changes of mitochondria were seen with swelling and decreased cristae.
These findings sugges that the lyosomal cnzymes, relcased from ischemic splanchnic area during arterial occlusion, were transported to the general circulation primarily via the thoracic duct and these cytotoxic enzymes played an important role in the pathogenesis of splanchnic ischemic shock in the experimental dogs.
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