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Effect of Splanchnic Artery Occlusion Induced Shock on the Lymph wnd Serum Acid Phosphatase Activity and Ultrastructural Changes of tho Hepatocyte of Dogs

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Abstract


This experiment was attempted to study the effect of splanchnic arteril occlusion (SAO) shock on the ultrastructural changes of the hepatocyte, the alerration of flow rate of thoracic duct lymph and the activity of serum and lymph acid phosphatase.
SAO shock was indueed by releasing the clamp after two hours occlusion of the splanchnic arterics in the experimental dogs.
Shortly after release of the occlusion, the mean arterial pressure feil to 60 mmHg, the flow of thoracic lymph inerased markedly, the blood pH decresed and the activity of lymph and serum acid phosphatase increased significantly.
The ultrastructure of the hepatocyte of SAO shock revealed degencrative changes characterized primarily by an apparent inercase in the number of secondary and post-lysosomes with vesiculation, vacuolation, fragmentation an ribosomal shedding of rER. Futhermore, degenerative changes of mitochondria were seen with swelling and decreased cristae.
These findings sugges that the lyosomal cnzymes, relcased from ischemic splanchnic area during arterial occlusion, were transported to the general circulation primarily via the thoracic duct and these cytotoxic enzymes played an important role in the pathogenesis of splanchnic ischemic shock in the experimental dogs.

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