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Cyclocytidine Hydrochloride의 正常흰쥐 血液像에 미치는 影響

Effect of Cyclocytidine Hydrochloride on Hematological Findings of Normal Rats

경북의대잡지 1977년 18권 1호 p.1 ~ 11
이규보, 黃基錫,
소속 상세정보
이규보 (  ) - 慶北大學校 醫科大學 核醫學敎室
黃基錫 (  ) - 慶北大學校 醫科大學 核醫學敎室

Abstract


The author evaluated tze effect of Cyclocytidine hydrochloride on peripheral blood cells as well as marro~.v cells by ~bsFrving for 26 days in the rats in;ected with the drug intraperitoneally.
There were aiterions of hemoglobin, reticulocyu: count, absolute neutrophil count, absolute lymphocyte count ant ~:atelet count in the rats being administered the drug at a dose of 15mg per kg corresponding to the therapeutic dose for humans for 5 days. No significant differences were noted in rlegak~_ryocyte count, nucleated. red ceIl count, absolute myeloid cell count, absolute lymphocyte count ar.d erythrocyte ~~Fe incorporation rate as compared with those of the control group.
In the rats given the drug at a dose of 150 mg per kg for 5 days, only the megakaryocyte count was found to be significantly decreased. Otherwise no abnormalities were seen.
The rats being given the drug at a dose of 3, 200 mg per kg corresponding to LD/50 dose for 5 days showed a marl:;dly decreased hemoglobin, significant reduction of various peripheral components, drastic decrease of erythrocyte ~~Fe incorporation as well as various myeloid cellular elements.

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