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Asbestos Fiber에 依한 肺胞壁의 微細形態學的變化

Fine Structural Study on Changes of Alveolar Wall Induced by Asbestos Fibers

경북의대잡지 1977년 18권 2호 p.145 ~ 157
이창수, 朴熙明, 孫泰重,
소속 상세정보
이창수 (  ) - 慶北大學校 醫科大學 內科學敎室
朴熙明 (  ) - 慶北大學校 醫科大學 內科學敎室
孫泰重 (  ) - 慶北大學校 醫科大學 病理學敎室

Abstract


This study was carried oat to know the early pathogenesis of pulmonary asbestosis. Rats were given intratracheal installation of chrysotile asbestas and early morphologic changes of alveolar wall were studied by light and electron microscopes as well as by means of cytochemistry.
Light microscopically, mild degree of changes, such as lymphocytic infiltration, congestion of capillaries and edema of alveolar wall, were found in 1 to 5 days after the installation. Seven to 12days afttr, above mentioned changes were more marked and also noted were swelling proliferation and desquamation of mucosal epithelial cells in bronchioles. The alveolar wall was thickened and infiltrated by lymphocytes, polymorphous, and monocytes with proliferation of fibrous tissue in the interstitium. In the alveolar spaces, desquamation of alveolar epithelial cells and erythrophagocytosis were found. Sixteen days after, proliferation of alveolar epithelial cells were noted with the other changes mentioned.
Electron microscopically, degeneration and decrease in osmiophilic boclies of type II cells and rE3 were noted after 1 to 3 days. Also noted in this period were proliferation of collagen fibrils, swelling of endothelial cells, mild prolifeartion of macrophages, and disrruption and decrease in alvelar surface lining layer. After 5 to 7 days, these changes became more marked and lattice-like structures were found in the alveolar spaces Vlicrovilli cf type II cells were flattened. L~-sosomes cf macrophages were increased. After ]2 days, then, changes were more severe `.viol marked increase in lattice-like structures and fibrillar structures in the alveolar space. Sixteen days after, these changes were more marked. Also noted were masses of fibrillar structures measuring about 150 to 450A in diameter between p~~oliferated collagen fibers. These masses were confirmed to contain silica and iron, the main components of chrysotile asbestos by EDAM system.
The results suggested that installation of chrysotile asbestos to the rats induced mechanical and chemical injuries to the alveolar surface lining layer containing surfactant, interstitium and the other alveolar components as well as macrophages. It was believed that derangements of these structures induced more ease intracellular introduction of asbestos fibril to develop progressive and severe proliferation of collagen fibers.

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