人蔘成分의 糖代謝에 미치는 影響
Effects of Korean Ginseng on Metabolism of Glucose in Rats
경북의대잡지 1977년 18권 2호 p.158 ~ 165
박성호, 曺準承,
소속 상세정보
박성호 ( ) - 慶北大學校 醫科大學 生化學敎室
曺準承 ( ) - 慶北大學校 醫科大學 生化學敎室
KMID : 0351619770180020158
Abstract
In order to see what effects the ginseng extract will bring upon the utilization and oxidation of glucose in the body, a methanol extract of the dried ginseng roots was prepared. The extract was injected into the peritoneal cavity of rats for .i days in the form of 5mg solution with 0.5m1 saline, per body weight of 100gm. The control group was injected with 0.5m1 of saline. The two groups were subdivided into the feeding and the starving ;24 hours), after one hour following the final administration of ginseng .extract and saline respectively, the groups were injected with 4~c of glucose-(U)-14C mixed with 100mg of glucose, per body weight of 100gm. After 3 hours observation of the oxidation rate of glucose, the effect of ginseng was studied on the utilization of glucose-(U)-14C in the biosynthesis of glycogen, total lipid and protein in the liver. The same study was made on protein and total lipid in the serum. The effect of ginseng administration on the glucose tolerance test was also observed.
The ginseng extract increased the oxidation rate of glucose, this increase was more notable in the starving state of rats. The extract also dropped the high level of loaded glucose.
The utilization rate of glucose-(U)-14C into total lipid in the liver and the serum showed a slight increase under a normal feeding administered with ginseng, but it decreased under starvation with ginseng. The incorporation rate of glucose-(U)-14C into protein in the liver and serum increased with the administration of ginseng, particularly in fasting state.
Without ginseng administration, the concentration of glycogen in liver showed afar more de-~crease in starving and remained unchanged when a,dministed with ginseng. However, effect of ginseng on the incorporation rate of glucose-(U)-14C into glycogen decreased slightly when feeding, but increased in starvation.
As the study shows ginseng extract expedites the oxidation of glucose. It also lowers the sugar level in hyperglycemia. It increases the utilization ei´fect of glucose for the biosynthesis of protein in the liver and the serum. Under a normal feeding, it decreases the sugar utilization into glycogen and increases the sugar conversions in the liver and the serum total lipid. But in starvation it shows a reverse effect.
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