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Cell Cycledptj ³H-thymidine 標職指數와 分裂指數가 일치하지 않는 原因

Comparative Analysis of Cell Population Kinetics on Esophageal Cell of Male Chicks.

경북의대잡지 1978년 19권 2호 p.207 ~ 220
주강,
소속 상세정보
주강 (  ) - 경북대학교 의과대학 해부학교실

Abstract

cycle에서 標識指數와 分裂指數가 일치하지 않는 원인을 알고저 Shaver種白色 Leghorn 수평아리를 오전 오후 실험군으로 나누어 3가지 方法에 의해서 검토 한 결과 다음과 같은 성적을 얻었다.
1. 分裂指數와 標識指數는 一致하지 않았다.
2. 世代時間(generation time)도 理論的 방법에 따라 實測値와 많은 차이가 있었으나 본인의 방법이 가장 實測値에 가까웠다.
3. 標識指數와 分裂指數가 一値하지 않은 原因의 한가지 說明으로 圖 4에 提示된바와 같은 model를 설정하였다.

The rate of cell proliferation and cell specialization are influenced by a wide variety factors in the microenvironment of the cell pepulation. The development of definitions of kinetic parameters related to cell proliferation, and the collection of quantitative data to estimate a few of the parameters, has facilitated the development and use of simplified ideal proliferative systems or models. Some of the methods to estimate comparative rate of cell proliferation in the renewing populations of the gastrointestinal tract, have used the ratio of the number of cells in DNA synthesis(S) or mitosis(MI), to the duaration of DNA synthesis (TG) or mitosis (TM), and have noted limitations of the estimate.
The cell cycle duaration has also been approximated by observing the time between successive waves of labeled mitoses after administration of tritiated thymidine.
In the present analysis, tritiated thymidine autoradiography has been applied to the esophageal epithelial cell population in two groups of male chicks, and then, comparative rates of cell proliferation were determined by observing the appearance of successive waves of labeled mitoses.
In addition, the theoretical models were compared to experimental data, in an attempt to gain further insight into nature of the differences between thelabe llring indeses and mitotic indeces. Theoretically all the cells which undergo DNA duplication should divide so that labelling indeces is in proportion to mitotic indeces in each cell population.
The result of many studies, however, tend not to be this theory. It seemed that all the and M. phase, cells which completed DNA duplication do not necessarily enter the mitotic phase directly. The auther, therefore, proposed another GO which tentatively between S phase and M phase, celled GO₂ and accordingly traditional GO is called GO.

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