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주정 중독 흰쥐에게 총담관 결찰이 간의 Xanthine Oxidase 활성에 미치는 영향

Effect of Common Bile Duct Ligation on Liver Xanthine Oxidase activity in Ethanol Intoxicated Rats

계명의대논문집 1994년 13권 1호 p.64 ~ 72
정성광, 김여희, 강회양,
소속 상세정보
정성광 (  ) - 계명대학교
김여희 (  ) - 계명대학교
강회양 (  ) - 계명대학교

Abstract


The activities of the hepatic and serum xanthine oxidase(XO) were studied in cholestasis induced by common bile duct (CBD) ligation and chronic ethanol intoxication and in cholestasis after acute ethanol intoxication to establish the biochemical
background of alcoholic hazard in hepatobiliary disease.
There were a marked increases in the serum and hepatic XO activities of rats treated with only acute ethanol intoxication. In the group with CBD ligation before acute ethanol intoxication, the activities of hepatic and serum XO increased more
significantly than in the groups with acute etnanol intoxication or in the group with only CBD ligation.
On the other hand, in the group with CBD ligation after chronic ethanol intoxication, the activity of serum XO increased more significantly than in the groups with chronic ethanol intoxication or in the group with only CBD ligation.
Viewed from above results, the hepatic XO seems to be an enzyme which increase its activity in acute ethanol intoxication. And the hepatic XO seems to be an enzyme which increase its activity in acute ethanol intoxication with cholestasis more
than
in
cholestasis; the cause of the increases seems to be the increment of biosynthesis. Especially when the acute and chronic ethanol intoxication with cholestasis occurred, the activity of serum XO was higher than that of the cholestasis because of
increased liver cell damage, which causes the enzyme to leak into the blood in great quantity.

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