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Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial

Journal of Ginseng Research 2021년 45권 1호 p.191 ~ 198
현선희, 안하영, 김형준, 김성원, 소승호, 인교, 박재규, 한창균,
소속 상세정보
현선희 ( Hyun Sun-Hee ) - Korea Ginseng Corporation Laboratory of Efficacy Research
안하영 ( Ahn Ha-Young ) - Semyung University Oriental Medical Hospital Department of Obstetrics and Gynecology
김형준 ( Kim Hyeong-Jun ) - Semyung University Oriental Medical Hospital Department of Obstetrics and Gynecology
김성원 ( Kim Sung-Won ) - Korea Ginseng Corporation Laboratory of Efficacy Research
소승호 ( So Seung-Ho ) - Korea Ginseng Corporation Laboratory of Efficacy Research
인교 ( In Gyo ) - Korea Ginseng Corporation Laboratory of Efficacy Research
박재규 ( Park Chae-Kyu ) - Korea Ginseng Corporation Laboratory of Efficacy Research
한창균 ( Han Chang-Kyun ) - Korea Ginseng Corporation Laboratory of Efficacy Research

Abstract


Background: Most clinical studies of immune responses activated by Korean Red Ginseng (KRG) have been conducted exclusively in patients. However, there is still a lack of clinical research on immune-boosting benefits of KRG for healthy persons. This study aims to confirm how KRG boosts the immune system of healthy subjects.

Methods: A total of 100 healthy adult subjects were randomly divided into two groups that took either a 2 g KRG tablet or a placebo per day for 8 weeks. The primary efficacy evaluation variables included changes in T cells, B cells, and white blood cells (WBCs) before and after eight weeks of KRG ingestion. Cytokines (TNF-α, INF-γ, IL-2 and IL-4), WBC differential count, and incidence of colds were measured in the secondary efficacy evaluation variables. Safety evaluation variables were used to identify changes in laboratory test results that incorporated adverse reactions, vital signs, hematological tests, blood chemistry tests, and urinalysis.

Results: Compared to the placebo group, the KRG intake group showed a significant increase in the number of T cells (CD3) and its subtypes (CD4 and CD8), B cells, and the WBC count before and after eight weeks of the intake. There were no clinically significant adverse reactions or other notable results in the safety evaluation factors observed.

Conclusion: This study has proven through its eight-week intake test and subsequent analysis that KRG boosts the immune system through an increase in T cells, B cells, and WBCs, and that it is safe according to the study's safety evaluation.

키워드

Immuno-enhancement; Korean Red Ginseng; T cell; B cell; White blood cell

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