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Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function

Journal of Ginseng Research 2021년 45권 2호 p.316 ~ 324
홍지택, 이민정, 윤상준, 신석표, 방창석, 백광호, 김동준, Youn Gi-Soo, 신민재, Ham Young-Lim, 석기태, 김봉수,
소속 상세정보
홍지택 ( Hong Ji-Taek ) - Hallym University Institute for Liver and Digestive Disease
이민정 ( Lee Min-Jung ) - Hallym University Department of Life Sciences
윤상준 ( Yoon Sang-Jun ) - Hallym University Institute for Liver and Digestive Disease
신석표 ( Shin Seok-Pyo ) - Hallym University Institute for Liver and Digestive Disease
방창석 ( Bang Chang-Seok ) - Hallym University Institute for Liver and Digestive Disease
백광호 ( Baik Gwang-Ho ) - Hallym University Institute for Liver and Digestive Disease
김동준 ( Kim Dong-Joon ) - Hallym University Institute for Liver and Digestive Disease
 ( Youn Gi-Soo ) - Hallym University Institute for Liver and Digestive Disease
신민재 ( Shin Min-Jea ) - Hallym University Institute for Liver and Digestive Disease
 ( Ham Young-Lim ) - Daewon University College Department of Nursing
석기태 ( Suk Ki-Tae ) - Hallym University Institute for Liver and Digestive Disease
김봉수 ( Kim Bong-Soo ) - Hallym University Department of Life Sciences

Abstract


Background: Korea Red Ginseng (KRG) has been used as remedies with hepato-protective effects in liver-related condition. Microbiota related gut-liver axis plays key roles in the pathogenesis of chronic liver disease. We evaluated the effect of KRG on gut-liver axis in patients with nonalcoholic statohepatitis by the modulation of gut-microbiota.

Methods: A total of 94 patients (KRG: 45 and placebo: 49) were prospectively randomized to receive KRG (2,000 mg/day, ginsenoside Rg1+Rb1+Rg3 4.5mg/g) or placebo during 30 days. Liver function test, cytokeraton 18, and fatigue score were measured. Gut microbiota was analyzed by MiSeq systems based on 16S rRNA genes.

Results: In KRG group, the mean levels (before vs. after) of aspartate aminotransferase (53 ± 19 vs. 45 ± 23 IU/L), alanine aminotransferase (75 ± 40 vs. 64 ± 39 IU/L) and fatigue score (33 ± 13 vs. 26 ± 13) were improved (p < 0.05). In placebo group, only fatigue score (34 ± 13 vs. 31 ± 15) was ameliorated (p < 0.05). The changes of phyla were not statistically significant on both groups. In KRG group, increased abundance of Lactobacillus was related with improved alanine aminotransferase level and increased abundance of Clostridium and Intestinibacter was associated with no improvement after KRG supplementation. In placebo group, increased abundance of Lachnospiraceae could be related with aggravation of liver enzyme (p < 0.05).

Conclusion: KRG effectively improved liver enzymes and fatigue score by modulating gut-microbiota in patients with fatty liver disease. Further studies are needed to understand the mechanism of improvement of nonalcoholic steatohepatitis.

키워드

fatty liver; ginseng; gut microbiota; nonalcoholic fatty liver disease

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